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Would like to ask about bujiale (estradiol) is oral or sublingual

Jan 29 20224 people replied
Description Of Condition:

Although the instructions say to take orally, some doctors say to take it under the tongue. I would like to ask if oral administration has a first pass effect and can be metabolized by about 60%. Will it hurt the liver if taken for a long time? Is it effective under the tongue? But will sublingual administration reduce the time of drug action due to rapid absorption? Three questions, thank you!

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