Novel coronavirus temporarily excluded? New research: unexplained hepatitis in children, or related to common viruses

2022-07-27 11:27:00

Under the premise that the COVID-19 is still raging around the world, another unknown reason is the emergence of acute hepatitis in children, which has once again strained the nerves of public health departments in all countries and regions in the world.

According to who statistics, more than 1000 children in more than 35 countries have been affected, most of whom are children under the age of 5. A total of 46 children need liver transplantation, including 22 deaths.

Is the severe acute hepatitis in children of unknown cause possibly related to the co infection of two common viruses?

Recently, Agence France Presse reported that two independent studies on children with unexplained liver injury or hepatitis in the UK found that almost all sick children had a virus called adeno-associated virus 2, which was not found in other children.

They found that the disease may be related to the co infection of two common viruses, but it has nothing to do with coronavirus.

Previously, many studies have found that adenovirus 41, a virus that can cause the common cold, may be related to this wave of acute hepatitis in children.

However, considering that this kind of virus mainly causes liver injury in children with low immune function, this kind of situation has not been found in children with complete immune system.

(distribution map of children with severe acute hepatitis of unknown cause on the WHO website /8 July 2022)

In addition, researchers also found another virus in most cases - adeno associated virus 2 (AAV2), which is generally considered harmless and cannot replicate in the host cell alone unless there is another "helper" virus.

In addition, the researchers also found that there was no evidence of novel coronavirus in the liver of patients, the covid-19 infection rate of children was not significantly higher than the average level of other children, and the number of cases did not increase with the increase of the number of covid-19 cases.

(a four-year-old Scottish patient with unexplained acute severe hepatitis)

What is the diagnostic basis for judging viral hepatitis?

1、 Pathogenic serological examination

For patients with hepatitis A, if the anti hav LGG is positive during the pathogenic serum blood test, it belongs to hepatitis A.

If HBsAg and HBS are positive, they belong to hepatitis B. HCV RNA positive belongs to hepatitis C, HDV RNA positive belongs to hepatitis D, and HEV RNA positive belongs to hepatitis B.

2、 Liver function test

After suffering from various viral hepatitis, patients' alanine aminotransferase and aspartate aminotransferase will increase. In addition, bilirubin and blood ammonia levels will also increase.

3、 Imaging examination

Through ultrasonic examination, we can clearly diagnose the space occupying lesions of the liver, and we can observe the actual damage degree of the patient's liver.

If the condition is serious, you may even see hydrops in the abdominal cavity.   

Will viral hepatitis affect your future life?

Viral hepatitis refers to a kind of viral hepatitis caused by infection with various hepatitis viruses.

There are many kinds of hepatitis viruses, which are divided into five types: A, B, C, D and Xu. Among them, a and Xu belong to acute infection, while B, C and D belong to chronic infection.

After suffering from viral hepatitis, the patient's liver function will change to a large extent, and the patient will repeatedly experience excessive fatigue, decreased appetite, nausea, repeated vomiting, skin pruritus and liver pain in daily life.

Patients will have jaundice, liver palms, spider moles or a series of neurological disorders, which will greatly affect the health and life of patients.

After suffering from viral hepatitis, if the treatment method is wrong or the daily nursing work is not done well, the liver cells will have a very large toxic reaction, which will lead to a large number of liver cell death, thus causing the liver to harden, and it is very likely to develop into liver cancer in the later stage.

In addition, after suffering from viral hepatitis, many patients will have a series of complications, such as upper gastrointestinal bleeding, hepatic encephalopathy and hepatorenal syndrome.

Therefore, once it is diagnosed as viral hepatitis, it is also necessary to seek medical treatment in time, and formulate corresponding treatment plans in combination with their own conditions.

#The latest discovery of unexplained acute hepatitis in children#

#The latest discovery of unexplained acute hepatitis in children#

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