Is leukemia an incurable disease? What symptoms indicate that the child has developed leukemia?

2022-07-26 15:00:00

When it comes to leukemia, people often think of Korean dramas.

Indeed, leukemia has also become one of the three routines indispensable to early Korean dramas. It seems that all lovers in the world are brothers and sisters after all, and one is also suffering from leukemia.

However, in everyone's eyes, leukemia seems to be particularly terrifying. After all, in TV dramas, these three words are synonymous with tragedy.

But in fact, leukemia, most people have not been scientifically recognized.

What kind of disease is leukemia?

Leukemia is a kind of malignant tumor disease of hematopoietic system, and the mortality caused by this disease ranks sixth among all malignant tumors.

According to the maturity and course of cell differentiation, the disease can be divided into acute and chronic. Among them, acute cell differentiation stagnates in the early stage, mostly primitive cells and early immature cells. The disease is relatively rapid, and the natural course is only a few months.

How did this disease happen?

The occurrence of the disease may be multi-step, and now it is believed that at least two molecular events are involved in the pathogenesis.

First, many reasons lead to the mutation of genes in some hematopoietic cells, thus activating a certain kind of signal pathway and generating clonal abnormal hematopoietic cells. These cells gain proliferation or survival advantage, and apoptosis is blocked.

The second is some genetic changes, which may affect some transcription factors, causing hematopoietic cell differentiation block or disorder.

In addition to these basic reasons, viral infection, abnormal immune function, chemical, physical and other factors may also induce the disease.

What are the symptoms of leukemia?

The bridge of Korean dramas is often like this - the protagonist suddenly finds out that he has nosebleed one day, and then goes to the hospital for examination to learn that he has leukemia.

Although such a bridge is reasonable, it does not mean all. Nosebleed is the first symptom of most leukemia patients, but not all leukemia have such manifestations.

These phenomena usually occur:

1. Anemia

Most patients have moderate to severe anemia at the time of seeing a doctor, but some acute patients have a short course of disease and can be free of anemia.

2. Fever and infection

Half of the patients have fever as their early manifestation, which can be low fever or high fever, of which the high fever temperature can reach 39 degrees to more than 40 degrees.

At the same time, high fever often indicates secondary infection, which can occur in various parts of the body, such as lungs, gums, perianal, etc., and sepsis can also occur in severe cases.

3. Bleeding

Nearly 40% of patients with early bleeding can occur in all parts of the body, of which epistaxis, menorrhagia, gum bleeding, skin ecchymosis and so on are the most common.

Intracranial hemorrhage, urinary bleeding and gastrointestinal bleeding are rare, but once they occur, they will have serious consequences.

4. Lymphadenopathy and splenomegaly

Lymphadenopathy is one of the significant characteristics of lymphocytic leukemia, among which acute lymphocytic leukemia is more common, while splenomegaly is more common in acute leukemia.

5. Bone and joint pain

Bone pain is one of the common signs of the disease, which is often severe and the part is not fixed. It mainly occurs in the limbs, spine, pelvis, sternum and so on. Even if the patient uses painkillers, it is difficult to alleviate it.

In addition, the disease can also infiltrate the respiratory, digestive and genitourinary systems, with diffuse or nodular changes in the lungs. At the same time, patients may also have pleural effusion, proteinuria, hematuria, digestive dysfunction, amenorrhea and other symptoms.

In addition, patients with severe central nervous system leukemia can also have symptoms such as facial paralysis and progressive paraplegia.

Suspected got leukaemia, how should do?

If these symptoms occur repeatedly and worsen significantly within a week, you need to see a doctor as soon as possible.

Go to the hematology department in time for blood routine examination, blood differentiation, bone marrow biopsy, cytochemical staining and other examinations. After investigation, targeted treatment should be carried out according to the specific type.

In particular, bone marrow puncture, although a traumatic operation, is essential for the clear diagnosis of leukemia and other blood system levels.

reference:

【1】 Cai Jingyi, Yang Zhigang, Tan Jianfeng, Wan Chonghua. Analysis of quality of life and its influencing factors in patients with acute leukemia [j]. Chinese Journal of disease control, 2014,18 (10): 935-939

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