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Thyroid hormone resistance syndrome

Thyroid hormone resistance syndrome (srth), also known as thyroid hormone refractory syndrome or thyroid hormone insensitivity syndrome (this), was first reported by refetoff in 1967. The disease is mostly familial, and there are a few sporadic cases, accounting for about 1 / 3. Mostly in children and adolescents, the youngest is newborns, both men and women. Clinical manifestations: serum free T4 (FT4) and free T3 (FT3) increased continuously, while thyroid stimulating hormone (TSH) was normal. The patient had no effects of drugs, non thyroid diseases and abnormal thyroid hormone transport.



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