Subacute combined degeneration of spinal cord in the elderly

Subacute degeneration of spinal cord is a neurodegenerative disease caused by vitamin B12 deficiency, which usually occurs together with pernicious anemia. The main lesions were in the posterior and lateral funiculus of the spinal cord. The clinical manifestations were deep sensory disturbance, sensory ataxia and spastic paralysis, accompanied by peripheral sensory disturbance. Some scholars believe that the damage of this disease is not limited to the spinal cord, but also the optic nerve and cerebral hemisphere. Moreover, the damage of spinal cord is not limited to the conduction bundle system of posterior and lateral funiculus, and the white matter of spinal cord can be damaged.