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Stiff person syndrome

Stiff person syndrome is a rare and serious central nervous system disease characterized by excessive contraction of trunk axis and lower limb muscles with myalgic muscle spasm. A variety of high titer autoantibodies can be detected in patients with other autoimmune diseases. The common clinical manifestations are persistent or fluctuating stiffness of trunk, limbs and neck muscles, plate-like firmness of abdominal muscles, and simultaneous involvement of active and antagonistic muscles. Benzodiazepines are the first choice for the treatment of this disease. If there are no complications, the prognosis is good.

Symptoms

Spinal syphilis

Spinal vascular disease

Tuberculous myelitis

Sympathetic chain syndrome

Tuberous sclerosis

Progressive spinal muscular atrophy

Spasm

Abstinence syndrome

Progressive hemifacial atrophy

Alcoholic brain atrophy

Staphylococcus aureus meningitis

Alcoholic amblyopia

Tendon tumor

Progressive lipodystrophy

Tension headache

Convulsion

Alcoholic myopathy

Progressive hypertrophic interstitial neuritis

Mental retardation

Alcoholic neuropathy

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