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Stiff person syndrome

Stiff person syndrome is a rare and serious central nervous system disease characterized by excessive contraction of trunk axis and lower limb muscles with myalgic muscle spasm. A variety of high titer autoantibodies can be detected in patients with other autoimmune diseases. The common clinical manifestations are persistent or fluctuating stiffness of trunk, limbs and neck muscles, plate-like firmness of abdominal muscles, and simultaneous involvement of active and antagonistic muscles. Benzodiazepines are the first choice for the treatment of this disease. If there are no complications, the prognosis is good.


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