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Renal damage in hyperthyroidism

Hyperthyroidism (hyperthyroidism for short) is a clinical syndrome caused by the increase of thyroid hormone level in blood circulation caused by many reasons. Clinically, it is characterized by hypermetabolic syndrome, goiter, exophthalmos, neurological and cardiovascular system dysfunction. Pathologically, the thyroid gland can show diffuse, nodular or mixed enlargement. The increase of thyroid hormone level in blood circulation can lead to a series of changes in kidney. There were mainly renal vasodilation, increased renal plasma flow, glomerular filtration rate, renal tubular resorption rate and excretion capacity. At the same time, due to the increase of renal medullary blood flow and the decrease of solute concentration in medulla, the osmotic pressure is reduced, resulting in the impairment of renal tubular concentration function. In hyperthyroidism, due to the increase of bone decomposition, moderate hypercalcemia can occur, resulting in renal lesions and even renal insufficiency. A few patients can be complicated with renal tubular acidosis.


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