Progressive spinal muscular atrophy
Progressive spinal muscular atrophy (SMA), also known as spinal muscular atrophy and spinal muscular atrophy, is a kind of disease caused by degeneration of motor neurons in the anterior horn of the spinal cord and motor nucleus of the brain stem. It is an autosomal recessive disease, which is not uncommon in clinic. According to the age of onset and the severity of myasthenia, it is clinically divided into sma-i type, sma-ii type and sma-iii type, namely infant type, intermediate type and juvenile type. The common feature is degeneration of spinal cord anterior horn cells. The clinical manifestations are progressive and symmetrical. Extensive flaccid paralysis and muscle atrophy dominated by proximal limbs. Intellectual development and sensation are normal, and the differences of various types are determined according to the age of onset, the speed of disease progression, the degree of myasthenia and the length of survival. So far, there is no specific and effective treatment for this disease. The main treatment measures are to prevent or treat various complications caused by severe myasthenia, such as pneumonia, malnutrition, skeletal deformity, mobility disorder and psychosocial problems.
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