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Bone marrow fibrosis (MF) is called myelofibrosis for short. It is a myeloproliferative disease caused by the proliferation of collagen in bone marrow hematopoietic tissue and its fibrous tissue seriously affecting hematopoietic function. Primary myelofibrosis is also known as "myelosclerosis" and "myeloid metaplasia of unknown cause". The disease has different degrees of bone marrow fibrous tissue hyperplasia, and extramedullary hematopoiesis mainly in the spleen, followed by liver and lymph nodes. The typical clinical manifestations are juvenile erythrocytic and granulocytic anemia, with more teardrop like erythrocytes. Dry pumping often occurs in bone marrow puncture, obvious enlargement of spleen and varying degrees of osteosclerosis.


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