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Methanol poisoning

The toxic effect of methanol on human body is caused by methanol and its metabolites formaldehyde and formic acid, which is mainly characterized by central nervous system damage, eye damage and metabolic acidosis. Methanol itself has anesthetic effect and direct toxic effect on nerve cells; Formic acid damages the optic papilla and optic nerve, resulting in optic papilledema, destruction of optic nerve myelin sheath and optic nerve damage; Methanol interferes with the metabolism of some oxidase in the body, causing the accumulation of lactic acid and other organic acids, and the production of methanol metabolite formic acid, leading to metabolic acidosis.


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