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Crohn's disease

Ochronosis is caused by the lack of urinary melanic acid oxidase, which makes the intermediate metabolites of phenylalanine and tyrosine (urinary melanic acid) unable to further oxidize and decompose and accumulate in the body. It darkens the color of skin, sclera and cartilage. At the same time, urinary black acid causes pigmentation of cartilage and other connective tissues, resulting in degenerative arthritis of spine and peripheral large joints. On the other hand, the black acid in urine is discharged with urine and turns black after alkalization and oxidation in urine, so it is also called alkaptonuria. This disease is a rare genetic disease. It is reported abroad that the prevalence rate is 3 ~ 5 cases per million population. Because urinary black acid is easy to deposit in cartilage, joint degeneration occurs. Joint disease often occurs in clinic, so it is called sallow joint disease.


Respiratory alkalosis

Respiratory acidosis

Erythropoietic porphyria

Erythropoietic protoporphyria

Suppurative osteomyelitis

Necrotizing sarcoidosis like granulomatosis

Mixed porphyria

Acquired circulating anticoagulant syndrome

Cavernous hemangioma thrombocytopenia syndrome

Acquired vitamin K-dependent coagulation factor abnormality

Acquired circulating anticoagulant syndrome

Acquired platelet dysfunction

acquired hemophilia

Pyrimidine 5 '- nucleotide deficiency

Huntington's disease dementia

IgA nephropathy

Type II renal tubular acidosis

Type I renal tubular acidosis

Type I diabetes mellitus


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