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Liver cirrhosis is a common chronic progressive liver disease in clinic. It is a diffuse liver damage caused by long-term or repeated action of one or more causes. In China, most of them are post hepatitis cirrhosis, and a few are alcoholic cirrhosis and schistosomiasis cirrhosis. Histopathologically, there are extensive hepatocyte necrosis, nodular regeneration of residual hepatocytes, connective tissue hyperplasia and fibrous septum formation, resulting in the destruction of hepatic lobule structure and the formation of pseudolobules. The liver gradually deforms and hardens and develops into liver cirrhosis. In the early stage, due to the strong compensatory function of the liver, there may be no obvious symptoms. In the later stage, the main manifestations are liver function damage and portal hypertension, with multiple system involvement. In the later stage, complications such as upper gastrointestinal bleeding, hepatic encephalopathy, secondary infection, hypersplenism, ascites, canceration and so on often occur. Liver cirrhosis is distributed all over the world, regardless of nationality or nationality, and seriously endangers people's health. The incidence rate of cirrhosis is not accurate. There is no accurate incidence rate in China. In 1987, the figures provided by WHO (WHO) showed that the average incidence rate of liver cirrhosis was about 17.1/10. According to the figures provided by 55 countries to the who, the number of deaths from liver cirrhosis worldwide exceeds 310000 every year, and has increased to 500000 in recent years. In Western Europe and the United States, the number of deaths due to liver cirrhosis ranks fifth after malignant tumors, cardiovascular diseases, cerebrovascular diseases and accidents. It is the fourth leading cause of death among middle-aged Americans. The incidence rate of different countries and different regions of the same country is also quite different. The developed western countries mainly take alcoholic cirrhosis, which accounts for more than 2/3 of all cirrhosis. The increase in alcohol consumption is the main reason for the increasing incidence rate of cirrhosis in these countries in recent years. The incidence rate of cirrhosis increased with the increase of alcohol consumption. For example, the incidence rate of alcoholic cirrhosis in France is 300/10 million, 3 times that of men. Alcohol consumption is greater than 40 ~ 50g/d, and the incidence rate rises to 2500/10 million. In 1960, the incidence rate of Bermingham in England was 5.6, /10 million. In 1974, it reached 153 / 100000 population. In France, the age-specific case fatality rate was 10 / 100000 in 1945 and rose to 40 / 100000 in 1967. The incidence rate of liver cirrhosis in China accounts for about 1% of the total number of hospitalized patients in the same period. However, in recent years, the incidence of alcoholic cirrhosis has increased significantly.




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