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Calcified valvular disease in the elderly

In 1904, monckebery first found that people will have degenerative changes in the process of natural aging, resulting in calcified aortic stenosis (CAS). Dewitsky first described mitral annular calcification (MAC) in 1910 and believed that the calcification was caused by degenerative changes. Since then, pathologists and clinicians systematically observed the changes of heart valves with age and confirmed that calcified heart valve disease is an elderly disease caused by valve aging, degenerative changes and calcium deposition, It is also called senile degenerative valvular disease or senile cardiac calcification syndrome.


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