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Acetaminophen poisoning

Acetaminophen (acetaminophen) has antipyretic and analgesic effects. The drug is absorbed rapidly from the gastrointestinal tract. The plasma concentration reaches the peak 30 ~ 120 minutes after oral administration. 90% of the drugs are combined with glucuronic acid and sulfuric acid in the liver and discharged from the urine; Only 2% ~ 4% were metabolized by the mixed function oxidase system of cytochrome P-450 in the liver, which became a toxic intermediate metabolite and combined with glutathione. After the latter is exhausted, unbound metabolites bind to hepatocyte proteins, resulting in hepatocyte necrosis. Adults can produce hepatotoxic effects by taking 7.5G orally at a time.


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